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Melatonin is a natural hormone produced by the pineal gland in the brain. It plays an essential role in regulating the body’s day-and-night rhythm, also known as the circadian rhythm. This rhythm can become disrupted when travelling across time zones, which may lead to jet lag. Melatonin supplements help restore the body’s natural sleep-wake cycle and ease symptoms of jet lag. As night falls, melatonin levels naturally rise, signalling to the body that it is time to rest. By binding to receptors that promote relaxation, melatonin supports a smoother transition to sleep.
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Sleep aid.
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Melatonin
Effects on sleep quality usually develop over the first few days; a full course of up to 13 weeks may be needed
Melatonin is a natural hormone produced by the pineal gland in the brain. It plays an essential role in regulating the body’s day-and-night rhythm, also known as the circadian rhythm. This rhythm can become disrupted when travelling across time zones, which may lead to jet lag. Melatonin supplements help restore the body’s natural sleep-wake cycle and ease symptoms of jet lag. As night falls, melatonin levels naturally rise, signalling to the body that it is time to rest. By binding to receptors that promote relaxation, melatonin supports a smoother transition to sleep.
Feeling tired or drowsy, Headache, Indigestion, nausea, or stomach discomfort, Irritability or restlessness, Dry or itchy skin, Vivid or unusual dreams
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Melatonin is a natural hormone that helps regulate the body's sleep and wake cycle. These 2mg modified release tablets support normal melatonin levels and healthy sleep patterns, including when adjusting to changes such as travel across time zones. They are a medicine that requires a clinician to assess whether they are suitable for you.
The pineal gland releases melatonin as daylight fades, and that rise is the signal that tells the body night has begun. A modified release tablet is designed to mimic that pattern: rather than delivering everything at once, it releases melatonin gradually across the night, which is why this form is generally used where staying asleep, not just falling asleep, is the difficulty.
Swallow the tablet whole with water at the time your clinician has specified, usually a set period before bed, and after food where directed. Do not crush, split or chew it, since that destroys the modified release and delivers the dose all at once. Keep the timing consistent, dim lights and screens beforehand and keep wake times steady, as melatonin works with those habits rather than instead of them.
It is for people where a clinician has assessed melatonin as suitable and confirmed the dose and duration. Your clinician needs to know about liver or kidney problems, autoimmune conditions, epilepsy and all other medicines you take, including anything that causes drowsiness.
Headache, daytime sleepiness, dizziness and nausea can occur, so do not drive or operate machinery until you know how it affects you, and avoid alcohol. Contact your clinician if sleep has not improved after the agreed trial period, if daytime grogginess is a problem, or before stopping or changing the dose. Persistent insomnia is worth investigating rather than treating indefinitely. Our UK pharmacy team can answer questions about this product before you buy.
Can I break the tablet?
No. Breaking it destroys the modified release and delivers the dose all at once.
Why does timing matter?
Melatonin shifts the body clock, so taking it at the agreed time is as important as the dose.
Is it habit forming?
It is not considered habit forming in the way sedatives are, but treatment should still be reviewed.
Always read the patient information leaflet supplied with the pack before use.
Medically reviewed and published
This page was medically reviewed by Dr Sohaib Imtiaz, Clinical Lead on
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Choose the medicine and dose you are on now, and when you last took it. We will show recommended starting doses for alternatives — including lower options a clinician may prefer. No login or personal details required.
Based on your current dose, you could switch to:
| Alternative medicine | Recommended start | Other doses you can take (incl. lower) |
|---|
Guidance only — a clinician must approve any switch. Based on clinical dosing switch guides.
Please read our FAQs page to find out more.
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