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At a glance

QUICK SUMMARY

01 Type of medicine

Antimalarial

02 Generic

No

03 Active ingredient

Atovaquone/Proguanil Hydrochloride

04 Effective within

Varies, see dosage instructions

05 Works by

Used for the prevention and treatment of malaria, a mosquito-borne infectious disease.

06 Side effects

Headache, nausea, vomiting, stomach pain, diarrhea, dizziness

MEDICATION DETAILS

Description

Malarone 250mg/100mg Tablets

Malarone is used to prevent and treat malaria, a serious and potentially life threatening disease spread by the bite of infected mosquitoes. It combines two active ingredients, atovaquone and proguanil, which work together against the malaria parasite in the blood. It is a medicine that requires a clinician to assess whether it is suitable for you and for your destination.

How it works

Atovaquone and proguanil each interfere with a different step the parasite needs to survive and multiply, and combining them makes it much harder for resistance to develop. Malarone also acts on the stage of the parasite in the liver as well as in the blood, which is why the course after returning is shorter than with some other antimalarials.

How to use it

Take the tablets exactly as directed, starting before travel, continuing every day while you are there and finishing the course after you return. Take them at the same time each day with food or a milky drink, since that improves absorption considerably. If you vomit within an hour of a dose, take another. Completing the post travel course matters, because stopping early leaves the liver stage untreated.

Who it is for

It is for travellers to malarial areas where a clinician has confirmed it is appropriate for that destination and for you. It is not suitable for anyone with severe kidney problems, and your clinician needs to know about pregnancy or breastfeeding, liver or kidney disease and all other medicines you take.

Safety and when to get advice

Nausea, headache, abdominal pain, diarrhoea and vivid dreams are commonly reported and are generally mild. No antimalarial is completely protective, so use repellent, cover up at dusk and dawn and sleep under a treated net as well. Seek urgent medical help for a fever during travel or in the weeks and months after returning, telling the clinician where you have been, since malaria can appear long after the trip. Our UK pharmacy team can answer questions about this product before you buy.

Common questions

When do I start and stop?
Before travel, daily while away, and for the stated period after returning. Your clinician will confirm the exact schedule.

Why take it with food?
Food or a milky drink substantially improves absorption.

Do I still need repellent?
Yes. No tablet is fully protective, so bite avoidance remains essential.

Always read the patient information leaflet supplied with the pack before use.

Directions

Before embarking on your malaria-exposed journey, it is imperative to internalize the ensuing instructions. Malarone serves a dual purpose: the prevention and treatment of malaria. Depending on your specific objective, adhere scrupulously to the prescribed dosing regimen.

Ingredients

The efficacy of Malarone emanates from its synergistic active constituents—namely, atovaquone and proguanil hydrochloride. These agents are encased within the tablet's core, a blend of poloxamer 188, microcrystalline cellulose, hydroxypropyl cellulose, povidone K30, sodium starch glycollate (Type A), and magnesium stearate. Enveloping this core is a coating comprising hypromellose, titanium dioxide (E171), iron oxide red (E172), macrogol 400, and polyethylene glycol 8000, which facilitates optimal delivery.

Side Effects

While Malarone undoubtedly stands as a stalwart guardian against malaria, it is pertinent to acknowledge the potential for side effects. These can span a spectrum from mild to severe. Vigilance is essential to detect signs of severe allergic reactions, skin aberrations, gastrointestinal disturbances, and other sporadic symptoms. In the event of such manifestations, immediate consultation with a healthcare professional is paramount.

Warnings

Prioritizing your safety is non-negotiable. Refrain from using Malarone if allergies to its constituents are evident or if severe renal impairment exists. Prudent consideration is warranted for those with the aforementioned conditions or if the weight of a child is below 11 kg. Equally significant is understanding potential interactions with concurrent medications. For expectant or nursing individuals, soliciting expert medical advice is indispensable before embarking on Malarone.

Medically reviewed and published

  • This page was medically reviewed by Dr Sohaib Imtiaz, Clinical Lead on Aug 24, 2023, 3:30 pm

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FAQs

Please read our FAQs page to find out more.

How does Malarone work to prevent malaria?

Malarone prevents malaria by killing the malaria parasite (Plasmodium falciparum) transmitted through mosquito bites. It helps protect individuals from getting infected in the first place.

Can Malarone be used for treating existing malaria infections?

Yes, Malarone can also be used to treat existing malaria infections. It effectively targets and eliminates the malaria parasites already present in the body.

Is Malarone safe to use during pregnancy and breastfeeding?

It is important to consult your doctor before taking Malarone if you are pregnant or breastfeeding. They will provide guidance on whether the benefits outweigh potential risks.

Can Malarone be taken with other medications?

Certain medications, such as metoclopramide, tetracycline, and certain HIV treatments, can interact with Malarone. Inform your doctor about any other medications you are taking to ensure safety.

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For assistance, please contact our customer service at info@rightangled.com. We are available Monday to Friday from 8 am to 5 pm. For urgent issues, please do not use this email. Instead, call 111, or dial 999 in case of an emergency.

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