At a glance

QUICK SUMMARY

01 Type of medicine

Vaginal Tablet

02 Generic

No

03 Active ingredient

Estradiol (as estradiol hemihydrate)

04 Effective within

Gradual improvement; symptoms may take a few months to improve

05 Works by

Replacing estrogen locally in the vagina to relieve menopausal symptoms

06 Side effects

Headache Stomach pain Vaginal bleeding, discharge, or discomfort Nausea Rash Weight increase Hot flush High blood pressure

Medication details

Description

Gina 10 Micrograms Vaginal Tablets

Gina is a low dose vaginal estrogen tablet for postmenopausal vaginal symptoms, and was the first postmenopausal hormone replacement therapy made available in the UK without a prescription. It is used for vaginal dryness, itching, soreness and pain during sex, and is supplied from a pharmacy following a short consultation.

How it works

After the menopause, falling estrogen levels cause the tissue of the vagina and vulva to become thinner, drier and less elastic, which is what produces the dryness, irritation and discomfort during sex. Gina delivers a very low dose of estradiol directly to that tissue, where it restores thickness, elasticity and natural lubrication. Because the dose is low and applied locally, very little is absorbed into the rest of the body.

How to use it

Insert one tablet into the vagina using the applicator supplied, following the pack instructions, usually daily at first and then twice weekly for maintenance. Bedtime suits most people. Symptoms generally improve over a few weeks rather than immediately, and continued use is needed to maintain the benefit.

Who it is for

Pharmacy supply is for postmenopausal women aged 50 to 65 who have not had a period for at least a year, following a consultation. It is not suitable where there is unexplained vaginal bleeding, a history of breast or other hormone dependent cancer, a history of blood clots, or certain liver conditions, which is what the consultation checks.

Safety and when to get advice

See a clinician promptly for any vaginal bleeding after the menopause, which always needs assessment, and for breast changes, pain or swelling in a leg, chest pain or sudden breathlessness. Contact a clinician if symptoms have not improved after around three months of use, or before continuing beyond the review period stated on the pack. Keep up routine breast screening and cervical screening invitations. Our UK pharmacy team can answer questions about this product.

Common questions

Is this the same as HRT tablets?
It is a local vaginal estrogen at a very low dose, which treats vaginal symptoms rather than flushes or night sweats.

How soon will it help?
Usually over a few weeks of regular use rather than straight away.

Can I use it with a vaginal moisturiser?
Often yes, and many people do. Ask a pharmacist about timing.

Always read the patient information leaflet supplied with the pack before use.

Directions

Gina is a vaginal tablet designed to alleviate menopausal symptoms in the vagina, such as dryness, irritation, soreness, itching, and discomfort during intercourse. This condition, known as "vaginal atrophy," is caused by a natural drop in estrogen levels after menopause. Gina works by releasing estradiol locally in the vagina to replenish the decreased estrogen levels and provide relief.

Ingredients

Each Gina vaginal tablet contains 10 micrograms of estradiol (as estradiol hemihydrate). Additional ingredients include hypromellose, lactose monohydrate, maize starch, magnesium stearate, and a film-coating comprising hypromellose and macrogol 6000.

Side Effects

As with any medication, Gina may cause side effects, although not everyone will experience them. Common side effects include headache, stomach pain, and vaginal bleeding, discharge, or discomfort. Uncommon side effects might include fungal genital infection, nausea, rash, weight increase, hot flush, and high blood pressure. Very rare side effects could entail diarrhea, water retention, worsened migraines, and generalized hypersensitivity. If you experience a serious allergic reaction or any severe side effects, discontinue use immediately and seek medical attention.

Warnings

Before using Gina, consult your pharmacist or doctor and disclose your medical history, especially if you have or have had womb or ovarian cancer, vaginal or genital bleeding, liver disease, blood clotting disorders, breast cancer, or other relevant conditions. Do not use Gina if you are allergic to estradiol or its ingredients, or if you have certain medical conditions. Seek prompt medical advice if you observe changes in your health or experience certain symptoms while using Gina.
Precautions
Regularly review your Gina treatment with your pharmacist and healthcare provider. Remember to attend recommended screenings and follow advice for breast and cervical health. If you have concerns about memory loss or other conditions, speak with your doctor. Keep in mind that Gina is not intended for use in children or adolescents, pregnant or breastfeeding women.
Storage and Disposal
Keep Gina out of reach of children and do not refrigerate. Do not use after the expiry date. To protect the environment, dispose of unused medicine properly.

Medically reviewed and published

  • This page was medically reviewed by Dr Sohaib Imtiaz, Clinical Lead on Aug 24, 2023, 3:30 pm

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FAQs

Please read our FAQs page to find out more.

Can Gina tablets be used for conditions other than menopausal vaginal symptoms?

No, Gina tablets are specifically designed for relieving menopausal symptoms in the vagina, such as dryness, irritation, and discomfort during intercourse. Consult your healthcare provider for guidance on alternative treatments for other conditions.

Is Gina suitable for women who have undergone a hysterectomy?

Yes, Gina can be considered for women who have had a hysterectomy. However, it's essential to discuss your medical history and current health status with your healthcare provider before using Gina.

Can I apply Gina vaginal tablets more frequently for faster relief?

It's important to follow the recommended dosing regimen for Gina as instructed. Using more than the prescribed dose may not necessarily lead to faster relief and could increase the risk of side effects. Consult your pharmacist or healthcare provider if you have concerns about your dosing schedule.

Can Gina vaginal tablets be used simultaneously with other vaginal products?

It's advisable to consult your healthcare provider before using multiple vaginal products at the same time. They can provide guidance on potential interactions and recommend the best approach to address your specific needs.

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