Differin Gel 0.1% (adapalene) - 50g

Name: Differin Gel 0.1% (adapalene) - 50g
Brand: Galderma
Price: 20.99 GBP
Availability: InStock

£ 20.99

Treatment of acne vulgaris, including blackheads, whiteheads, and inflamed pimples.

Adapalene, a topical retinoid that helps unclog pores, normalise skin-cell turnover, and reduce inflammation associated with acne.

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Differin Gel 0.1% (adapalene) - 50g

£ 20.99

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01 Type of medicine

Topical retinoid

02 Generic

03 Active ingredient

04 Effective within

05 Works by

Adapalene, a topical retinoid that helps unclog pores, normalise skin-cell turnover, and reduce inflammation associated with acne.

06 Side effects

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MEDICATION DETAILS

Description

Differin Gel 0.1% (adapalene) is a topical retinoid formulated to help treat and prevent acne. The 50g gel is designed for regular use on acne-prone skin and helps keep pores clear while supporting a more even, smoother-looking complexion.

Differin contains adapalene 0.1%, which works inside the hair follicles where acne develops. It helps regulate the process of skin-cell turnover and reduces the tendency of dead skin cells to build up and clog pores. By helping prevent clogged pores from forming, adapalene can reduce the development of new blackheads, whiteheads, and inflammatory acne lesions.

With consistent use, Differin can help improve the overall appearance of acne-prone skin. Results may take several weeks, and continued use is generally needed to maintain improvement.

Directions

Apply a thin layer of Differin 0.1% Gel to clean, dry, acne affected skin once daily in the evening, avoiding the eyes, lips, and other sensitive areas, and wash your hands after application.

Ingredients

Adapalene 0.1% w/w (active ingredient), carbomer 940, propylene glycol (E1520), poloxamer 182, disodium edetate, methylparahydroxybenzoate (E218), phenoxyethanol, sodium hydroxide, and purified water.

Side Effects

Differin 0.1% Gel may cause dry skin, skin irritation, burning or stinging, redness, peeling, itching, skin discomfort, sunburn, and local skin reactions. Rarely, allergic reactions, swelling, skin discolouration, or application-site burns may occur. Seek urgent medical attention if you experience facial or throat swelling, difficulty breathing, hives, or severe dizziness.

Warnings

For external use only. Avoid contact with eyes and lips. Do not use on damaged or sunburned skin. Avoid excessive sun or UV exposure. Do not use during pregnancy. Stop use if severe irritation occurs and consult a healthcare professional.

Medically reviewed and published

This page was medically reviewed by Dr Sohaib Imtiaz, Clinical Lead on Aug 25, 2026, 2:30 pm

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FAQs

Please read our FAQs page to find out more.

What is Differin 0.1% Gel used for?

Differin 0.1% Gel is used to treat acne vulgaris, including blackheads, whiteheads and inflamed spots.

What is the active ingredient in Differin Gel?

The active ingredient is adapalene 0.1% w/w, a topical retinoid.

How should Differin 0.1% Gel be applied?

Apply a thin layer to clean, dry, acne-affected skin once daily in the evening, as directed by your doctor or pharmacist.

What are the common side effects?

Common side effects include dryness, redness, peeling, itching, burning or skin irritation, particularly during the first few weeks.

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